The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …

The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the
underlying mechanism and its pathogenic role remain elusive. We show that autophagy was …

Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

Cardiac progenitor cells derived from adult heart have emerged as one of the most
promising stem cell types for cardiac protection and repair. Exosomes are known to mediate …

The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

Myocardial infarction is a leading cause of death among all cardiovascular diseases. The
analysis of molecular mechanisms by which the ischemic myocardium initiates repair and …