CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

Regulatory B (Breg) cells are characterized by differential expression of CD5 and CD1d in
mouse and CD24 and CD38 in human immune systems. The Breg family also includes LAG …

The development of cancer is a multistep and complex process involving interactions
between tumor cells and the tumor microenvironment (TME). CXC chemokine ligand 13 …

Increased expression of complement C1r, C1s and C3 in kidney cells plays an important
role in the pathogenesis of kidney fibrosis. Our studies suggest that activation of complement …

Renal ischemia-reperfusion injury (IRI) is a non-negligible clinical challenge for clinicians in
surgeries such as renal transplantation. Functional loss of renal tubular epithelial cell (TEC) …

B1 lymphocytes may be subdivided by CD5 and CD11b/Mac1 expression into B1a, with the
CD5 and CD11b/Mac1 phenotype, and B1b, which present as CD19 hi CD5 lo CD11b hi …

The complement system (CS) is an ancient and highly conserved part of the innate immune
system with important functions in immune defense. The multiple fragments bind to specific …

Abstract T cell–independent (TI) B cell responses to nonprotein Ags involve multiple cues
from the innate immune system. Neutrophils express complement receptors and activated …

The overpowering effect of trauma on the immune system is undisputed. Severe trauma is
characterized by systemic cytokine generation, activation and dysregulation of systemic …

We have previously reported that increased expression and activation of kidney cell
complement components play an important role in the pathogenesis of renal scarring. Here …