Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in
the literature, there is still confusion regarding its pathogenesis and clinical significance …

Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) …

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third
greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite …

The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular–
organ interaction is a key mechanism and a concept that enables an understanding of all …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Chronic liver disease is associated with remarkable alterations in the intra-and extrahepatic
vasculature. Because of these changes, the fields of liver vasculature and portal …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

Sorafenib, an orally-available kinase inhibitor, is the only standard clinical treatment against
advanced hepatocellular carcinoma. However, development of resistance to sorafenib has …

Objectives In chronic liver injury, angiogenesis, the formation of new blood vessels from pre-
existing ones, may contribute to progressive hepatic fibrosis and to development of …