Introduction In order to assess the significance of drug levels measured in intensive care
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …

Based on findings that the cardiotoxicity infrequently observed with racemic bupivacaine
shows enantioselectivity, ie it is more pronounced with the R (+)-enantiomer, the S (−) …

In order to assess the significance of drug levels measured in clinical and forensic toxicology
as well as for Therapeutic Drug Monitoring (TDM) it is essential that good collections of data …

Background: Although numerous methods of postoperative analgesia have been
investigated in an attempt to improve pain control after total knee arthroplasty, parenteral …

Ropivacaine is a long-acting, enantiomerically pure (S-enantiomer) amide local anaesthetic
with a high pK a and low lipid solubility which blocks nerve fibres involved in pain …

The currently available local anaesthetic agents are capable of providing high quality nerve
blockade in a wide variety of clinical circumstances. Our understanding of the mechanisms …

BACKGROUND: Up to two-thirds of patients report moderate to severe surgical site pain
after craniotomy procedures, and there is understandable reluctance to manage these …

The complications of failure, neural injury and local anaesthetic toxicity are common to all
regional anaesthetic techniques, and individual techniques are associated with specific …

Background The rationale of this study was to evaluate intrathecal ropivacaine for
ambulatory surgery. Methods One hundred fifty patients with American Society of …

The choice of local anaesthetic is influenced by several factors; it must provide effective
anaesthesia and analgesia for the duration of the procedure and meet the expectations for …