A brief history of synthetic biology
The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …
back more than a half-century. With the genomics revolution and rise of systems biology in …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Artificial intelligence and personalized medicine
NJ Schork - Precision medicine in Cancer therapy, 2019 - Springer
The development of high-throughput, data-intensive biomedical research assays and
technologies has created a need for researchers to develop strategies for analyzing …
technologies has created a need for researchers to develop strategies for analyzing …
Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system
Differential mRNA expression studies implicitly assume that changes in mRNA expression
have biological meaning, most likely mediated by corresponding changes in protein levels …
have biological meaning, most likely mediated by corresponding changes in protein levels …
Anti‐ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery
CY Shen, JG Jiang, L Yang… - British Journal of …, 2017 - Wiley Online Library
Ageing, an unanswered question in the medical field, is a multifactorial process that results
in a progressive functional decline in cells, tissues and organisms. Although it is impossible …
in a progressive functional decline in cells, tissues and organisms. Although it is impossible …
Mass spectrometry applied to bottom-up proteomics: entering the high-throughput era for hypothesis testing
LC Gillet, A Leitner, R Aebersold - Annual review of analytical …, 2016 - annualreviews.org
Proteins constitute a key class of molecular components that perform essential biochemical
reactions in living cells. Whether the aim is to extensively characterize a given protein or to …
reactions in living cells. Whether the aim is to extensively characterize a given protein or to …
[HTML][HTML] Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ
Biological processes are regulated by intermolecular interactions and chemical
modifications that do not affect protein levels, thus escaping detection in classical proteomic …
modifications that do not affect protein levels, thus escaping detection in classical proteomic …
Systems biology primer: the basic methods and approaches
I Tavassoly, J Goldfarb, R Iyengar - Essays in biochemistry, 2018 - portlandpress.com
Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …
single biological scale and also among different scales (eg cells, tissues and organ systems) …
Network biology: understanding the cell's functional organization
AL Barabasi, ZN Oltvai - Nature reviews genetics, 2004 - nature.com
A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …
and their interactions within a living cell. There is a clear need to understand how these …
Mass spectrometry-based proteomics
R Aebersold, M Mann - Nature, 2003 - nature.com
Recent successes illustrate the role of mass spectrometry-based proteomics as an
indispensable tool for molecular and cellular biology and for the emerging field of systems …
indispensable tool for molecular and cellular biology and for the emerging field of systems …