Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities
SK Pirooznia, F Elefant - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by
which neurons adapt their transcriptional responses to specific developmental and …
which neurons adapt their transcriptional responses to specific developmental and …
Modulating epigenetic HAT activity for reinstating acetylation homeostasis: a promising therapeutic strategy for neurological disorders
Epigenetic mechanisms are emerging as a fundamental regulatory switch in neuronal
function. Acetylation homeostasis governed by the antagonistic activities of HATs and …
function. Acetylation homeostasis governed by the antagonistic activities of HATs and …
Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis
S Forostyak, P Jendelova, M Kapcalova, D Arboleda… - …, 2011 - Taylor & Francis
Background aims. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disorder characterized by the loss of brain and spinal cord motor neurons (MN). The …
disorder characterized by the loss of brain and spinal cord motor neurons (MN). The …
Vitamin A deficiency impairs spatial learning and memory: the mechanism of abnormal CBP-dependent histone acetylation regulated by retinoic acid receptor alpha
N Hou, L Ren, M Gong, Y Bi, Y Gu, Z Dong, Y Liu… - Molecular …, 2015 - Springer
Vitamin A (VA) is an essential micronutrient. Numerous studies have confirmed that VA
deficiency (VAD) leads to a decline in learning and memory function. Our previous studies …
deficiency (VAD) leads to a decline in learning and memory function. Our previous studies …
Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper …
E Tokuda, E Okawa, S Watanabe, S Ono… - Neurobiology of …, 2013 - Elsevier
Over 170 mutations in superoxide dismutase-1 (SOD1) have been linked to amyotrophic
lateral sclerosis (ALS). The properties of SOD1 mutants differ considerably including copper …
lateral sclerosis (ALS). The properties of SOD1 mutants differ considerably including copper …
Epigenetic mechanisms of gene regulation in amyotrophic lateral sclerosis
Despite being clinically described 150 years ago, the mechanisms underlying amyotrophic
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …
Neuromuscular effects of G93A-SOD1 expression in zebrafish
SA Sakowski, JS Lunn, AS Busta, SS Oh… - Molecular …, 2012 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal disorder involving the
degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are …
degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are …
The peripheral nervous system in amyotrophic lateral sclerosis: opportunities for translational research
Although amyotrophic lateral sclerosis (ALS) has been considered as a disorder of the motor
neuron (MN) cell body, recent evidences show the non-cell-autonomous pathogenic nature …
neuron (MN) cell body, recent evidences show the non-cell-autonomous pathogenic nature …
Valproic acid regulates antioxidant enzymes and prevents ischemia/reperfusion injury in the rat retina
ZZ Zhang, XH Qin, XF Zhao, N Tong, YY Gong… - Current eye …, 2012 - Taylor & Francis
Purposes: To investigate whether valproic acid (VPA) has a neuroprotective effect against
ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate the potential antioxidant …
ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate the potential antioxidant …
Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
Background The development of new therapeutic strategies to treat amyotrophic lateral
sclerosis (ALS) is of utmost importance. The use of cyclic nitroxides such as tempol may …
sclerosis (ALS) is of utmost importance. The use of cyclic nitroxides such as tempol may …