Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Using MetaboAnalyst 4.0 for metabolomics data analysis, interpretation, and integration with other omics data

J Chong, J Xia - Computational methods and data analysis for …, 2020 - Springer
Abstract MetaboAnalyst (www. metaboanalyst. ca) is an easy-to-use, comprehensive web-
based tool, freely available for metabolomics data processing, statistical analysis, functional …

The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research

AHM Emwas - Metabonomics: Methods and protocols, 2015 - Springer
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) have evolved as the most
common techniques in metabolomics studies, and each brings its own advantages and …

[HTML][HTML] The food metabolome: a window over dietary exposure

A Scalbert, L Brennan, C Manach… - The American journal of …, 2014 - Elsevier
The food metabolome is defined as the part of the human metabolome directly derived from
the digestion and biotransformation of foods and their constituents. With> 25,000 …

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

WB Dunn, A Erban, RJM Weber, DJ Creek, M Brown… - Metabolomics, 2013 - Springer
Metabolomics has advanced significantly in the past 10 years with important developments
related to hardware, software and methodologies and an increasing complexity of …

Current practice of liquid chromatography–mass spectrometry in metabolomics and metabonomics

HG Gika, GA Theodoridis, RS Plumb… - Journal of pharmaceutical …, 2014 - Elsevier
Based on publication and citation numbers liquid chromatography (LC–MS) has become the
major analytical technology in the field of global metabolite profiling. This dominance reflects …

Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry

D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …

Liquid chromatography–mass spectrometry based global metabolite profiling: a review

GA Theodoridis, HG Gika, EJ Want, ID Wilson - Analytica chimica acta, 2012 - Elsevier
Untargeted, global metabolite profiling (often described as metabonomics or metabolomics)
represents an expanding research topic and is, potentially, a major pillar for systems biology …

HILIC‐MS for metabolomics: An attractive and complementary approach to RPLC‐MS

DQ Tang, L Zou, XX Yin, CN Ong - Mass spectrometry reviews, 2016 - Wiley Online Library
Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …

Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry

J Zhou, Y Yin - Analyst, 2016 - pubs.rsc.org
Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …