Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Recent evidence suggests that calorie restriction and specifically reduced glucose
metabolism induces mitochondrial metabolism to extend life span in various model …

Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to
extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms …

Increasing cellular glucose uptake is a fundamental concept in treatment of type 2 diabetes,
whereas nutritive calorie restriction increases life expectancy. We show here that increased …

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …

Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we
report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide …

Calorie restriction (CR) is the only experimental manipulation that is known to extend the
lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non …

Dietary restriction (DR) has the remarkable ability to extend lifespan and healthspan. A
variety of DR regimens have been described in species ranging from yeast to mammals …

A nutritious diet low in calories improves the health and extends the life span of rodents.
Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and …

Dietary restriction extends lifespan and retards age-related disease in many species and
profoundly alters endocrine function in mammals. However, no causal role of any hormonal …