Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC

X Niu, L Chen, Y Li, Z Hu, F He - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …

Small cell lung cancer transformation: From pathogenesis to treatment

X Yin, Y Li, H Wang, T Jia, E Wang, Y Luo, Y Wei… - seminars in Cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is a type of neuroendocrine tumor with high malignancy and
poor prognosis. Besides the de novo SCLC, there is transformed SCLC, which has similar …

FOXM1: A small fox that makes more tracks for cancer progression and metastasis

MA Khan, P Khan, A Ahmad, M Fatima… - Seminars in Cancer …, 2023 - Elsevier
Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

RNA-based therapies: a cog in the wheel of lung cancer defense

P Khan, JA Siddiqui, I Lakshmanan, AK Ganti, R Salgia… - Molecular cancer, 2021 - Springer
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity

AP Szczepanski, N Tsuboyama, J Watanabe… - Science …, 2022 - science.org
Small cell lung cancer (SCLC), accounting for around 13% of all lung cancers, often results
in rapid tumor growth, early metastasis, and acquired therapeutic resistance. The POU class …

[HTML][HTML] Small cell lung cancer: novel treatments beyond immunotherapy

JJ Meijer, A Leonetti, G Airò, M Tiseo, C Rolfo… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) arises in peribronchial locations and infiltrates the bronchial
submucosa, including about 15% of lung cancer cases. Despite decades of research, the …

m6A regulators as predictive biomarkers for chemotherapy benefit and potential therapeutic targets for overcoming chemotherapy resistance in small-cell lung cancer

Z Zhang, C Zhang, Z Yang, G Zhang, P Wu… - Journal of Hematology & …, 2021 - Springer
Small-cell lung cancer (SCLC) is a devastating subtype of lung cancer with few therapeutic
options. Despite the advent of immunotherapy, platinum-based chemotherapy is still the …

Emerging role of chemokines in small cell lung cancer: Road signs for metastasis, heterogeneity, and immune response

P Khan, M Fatima, MA Khan, SK Batra… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is a recalcitrant, relatively immune-cold, and deadly subtype
of lung cancer. SCLC has been viewed as a single or homogenous disease that includes …

MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis

P Khan, JA Siddiqui, PG Kshirsagar, RC Venkata… - Molecular cancer, 2023 - Springer
Background Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is
associated with high recurrence and poor prognosis. Due to lack of potential drug targets …

Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer

N Tsuboyama, R Wang, AP Szczepanski, H Chen… - Oncogene, 2022 - nature.com
Small cell lung cancer (SCLC) is an aggressive disease, with patients diagnosed with either
early-stage, limited stage, or extensive stage of SCLC tumor progression. Discovering and …