Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development
C Aspord, A Pedroza-Gonzalez, M Gallegos… - The Journal of …, 2007 - rupress.org
We previously reported (Bell, D., P. Chomarat, D. Broyles, G. Netto, GM Harb, S. Lebecque,
J. Valladeau, J. Davoust, KA Palucka, and J. Banchereau. 1999. J. Exp. Med. 190: 1417 …
J. Valladeau, J. Davoust, KA Palucka, and J. Banchereau. 1999. J. Exp. Med. 190: 1417 …
IL-10 as a Th2 cytokine: differences between mice and humans
The discovery of IL-10 more than 30 years ago marked the beginning of our understanding
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …
An epigenetic view of helper T cell differentiation
Antigen and cytokine receptor signals act in synergy to direct the differentiation of CD4+ T
cells. These signals initiate reciprocal activation and silencing of the interferon-γ (IFN-γ) and …
cells. These signals initiate reciprocal activation and silencing of the interferon-γ (IFN-γ) and …
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
RG Jenner, MJ Townsend, I Jackson… - Proceedings of the …, 2009 - National Acad Sciences
Upon detection of antigen, CD4+ T helper (Th) cells can differentiate into a number of
effector types that tailor the immune response to different pathogens. Alternative Th1 and …
effector types that tailor the immune response to different pathogens. Alternative Th1 and …
Epigenetic drug discovery: breaking through the immune barrier
Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …
[HTML][HTML] Pro-and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells
Activated monocytes produce proinflammatory cytokines (monokines) such as interleukin
(IL)-12, IL-15, and IL-18 for induction of interferon-γ (IFN-γ) by natural killer (NK) cells. NK …
(IL)-12, IL-15, and IL-18 for induction of interferon-γ (IFN-γ) by natural killer (NK) cells. NK …
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
L Rivino, M Messi, D Jarrossay… - The Journal of …, 2004 - rupress.org
We previously reported that central–memory T cells (TCM cells), which express lymph node
homing receptors CCR7 and CD62L, are largely devoid of effector functions but acquire …
homing receptors CCR7 and CD62L, are largely devoid of effector functions but acquire …
[HTML][HTML] T helper cell differentiation: regulation by cis elements and epigenetics
Cytokine loci undergo changes in chromatin structure when naive CD4+ T cells differentiate
into Th1 or Th2 cells and have also been examined for regulatory sequences underlying …
into Th1 or Th2 cells and have also been examined for regulatory sequences underlying …
Histone hyperacetylation is associated with amelioration of experimental colitis in mice
R Glauben, A Batra, I Fedke, M Zeitz… - The Journal of …, 2006 - journals.aai.org
Inhibitors of histone deacetylases (HDAC) are being studied for their antiproliferative effects
in preclinical cancer trials. Recent studies suggest an anti-inflammatory role for this class of …
in preclinical cancer trials. Recent studies suggest an anti-inflammatory role for this class of …
[HTML][HTML] Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
Activating intra-tumor innate immunity might enhance tumor immune surveillance.
Virotherapy is proposed to achieve tumor cell killing, while indirectly activating innate …
Virotherapy is proposed to achieve tumor cell killing, while indirectly activating innate …