Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
HG Evans, T Suddason, I Jackson… - Proceedings of the …, 2007 - National Acad Sciences
Recently, a new lineage of CD4+ T cells has been described in the mouse that specifically
secretes IL-17 [T helper (Th) 17]. This discovery has led to a revision of the hypothesis that …
secretes IL-17 [T helper (Th) 17]. This discovery has led to a revision of the hypothesis that …
The transcription factor Ets1 suppresses T follicular helper type 2 cell differentiation to halt the onset of systemic lupus erythematosus
Single-nucleotide polymorphisms in ETS1 are associated with systemic lupus
erythematosus (SLE). Ets1−/− mice develop SLE-like symptoms, suggesting that …
erythematosus (SLE). Ets1−/− mice develop SLE-like symptoms, suggesting that …
Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4+ T Cells
DA Kulpa, A Talla, JH Brehm, SP Ribeiro… - Journal of …, 2019 - Am Soc Microbiol
During antiretroviral therapy (ART), human immunodeficiency virus type 1 (HIV-1) persists
as a latent reservoir in CD4+ T cell subsets in central memory (TCM), transitional memory …
as a latent reservoir in CD4+ T cell subsets in central memory (TCM), transitional memory …
T helper cell subsets: diversification of the field
CE Zielinski - European journal of immunology, 2023 - Wiley Online Library
Polarized T helper cell (Th cell) responses are important determinants of host protection. Th
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …
A skin-selective homing mechanism for human immune surveillance T cells
P Schaerli, L Ebert, K Willimann, A Blaser… - The Journal of …, 2004 - rupress.org
Effective immune surveillance is essential for maintaining protection and homeostasis of
peripheral tissues. However, mechanisms controlling memory T cell migration to peripheral …
peripheral tissues. However, mechanisms controlling memory T cell migration to peripheral …
The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes
A Hertweck, M Vila de Mucha, PR Barber… - Nucleic Acids …, 2022 - academic.oup.com
Lineage-determining transcription factors (LD-TFs) drive the differentiation of progenitor
cells into a specific lineage. In CD4+ T cells, T-bet dictates differentiation of the TH1 lineage …
cells into a specific lineage. In CD4+ T cells, T-bet dictates differentiation of the TH1 lineage …
Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1–infected patients and respond to Candida albicans
D Fenoglio, A Poggi, S Catellani… - Blood, The Journal …, 2009 - ashpublications.org
In early HIV-1 infection, Vδ1 T lymphocytes are increased in peripheral blood and this is
related to chemokine receptor expression, chemokine response, and recirculation. Herein …
related to chemokine receptor expression, chemokine response, and recirculation. Herein …
The CD4-centered universe of human T cell subsets
Humans are continuously exposed to a high number of diverse pathogens that induce
different types of immune responses. Primary pathogen-specific immune responses …
different types of immune responses. Primary pathogen-specific immune responses …
[HTML][HTML] High-dimensional T helper cell profiling reveals a broad diversity of stably committed effector states and uncovers interlineage relationships
L Tortola, A Jacobs, L Pohlmeier, FJ Obermair… - Immunity, 2020 - cell.com
Summary CD4+ T helper (Th) cells are fundamental players in immunity. Based on the
expression of signature cytokines and transcription factors, several Th subsets have been …
expression of signature cytokines and transcription factors, several Th subsets have been …
[HTML][HTML] Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses
QQ Chen, L Yan, CZ Wang, WH Wang… - World Journal of …, 2013 - ncbi.nlm.nih.gov
AIM: To investigate the potential therapeutic effects of mesenchymal stem cells (MSCs) in
inflammatory bowel disease (IBD), we transplanted MSCs into an experimental model of …
inflammatory bowel disease (IBD), we transplanted MSCs into an experimental model of …