The incidence of allergic diseases has increased over the past 50 years, likely due to
environmental factors. However, the nature of these factors and the mode of action by which …

Cytotoxicity and IFN-γ production by human γδ T cells underlie their potent antitumor
functions. However, it remains unclear where and how human γδ T cells acquire these key …

Clinical and experimental studies show that inhibition of histone/protein deacetylases
(HDAC) can have important anti-neoplastic effects through cytotoxic and proapoptotic …

Th cells integrate signals from their microenvironment to acquire distinct specialization
programs for efficient clearance of diverse pathogens or for immunotolerance. Ionic signals …

Many vaccination strategies and immune cell therapies aim at increasing the numbers of
memory T cells reactive to protective antigens. However, the differentiation lineage and …

Memory T cells possess functional differences from naïve T cells that powerfully contribute to
the efficiency of secondary immune responses. These abilities are imprinted during the …

Objectives. Graft-versus-host disease (GVHD) is a major obstacle to safe allogeneic
hematopoietic stem-cell transplantation, leading to significant mortality. Recently, T-helper …

The contribution of Th1 and Th17 cells in chronic inflammatory conditions leading to
autoimmunity remains highly controversial. In inflamed tissues, production of prostaglandins …

The linear model of Th cell lineage commitment is being revised due to reports that mature
Th cells can trans-differentiate into alternate lineages. This ability of Th cells to reprogram is …

Differentiation of uncommitted T cells into Th1 and Th2 subpopulations depends on both
intracellular events controlling expression of transcription factors T-bet and GATA-3 and …