Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …

Abstract 17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …

Background Treatment guidelines recommend the regular use of inhaled corticosteroids for
patients with mild persistent asthma. We investigated whether the symptom-driven use of a …

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases,
with therapeutic strategies and the range of technology significantly evolving in recent years …

BACKGROUND. Evidence from rodent studies indicates that the sympathetic nervous
system (SNS) regulates bone metabolism, principally via β2-adrenergic receptors (β2-ARs) …

This is the fourth version of the updated guidelines for the diagnosis and management of
asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi …

Rationale: Inhaled β-agonists are one of the most widely used classes of drugs for the
treatment of asthma. However, a substantial proportion of patients with asthma do not have a …

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation
of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling …

Indacaterol is a novel β2-adrenoceptor agonist in development for the once-daily treatment
of asthma and chronic obstructive pulmonary disease. The present study evaluated the …