Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

Dietary interventions have emerged as effective environmental inducers of brain plasticity.
Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a …

Intensive research in the last decade shows that the prototypic angiogenic factor vascular
endothelial growth factor (VEGF) can have direct effects in neurons and modulate processes …

Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Background: Omega-3 polyunsaturated fatty acids (n-3 PUFA) are structural components of
the brain and are indispensable for neuronal membrane synthesis. Along with decline in …

Severe and prolonged stress is the main environmental factor that precipitates depression,
anxiety and cognitive dysfunctions. On the other hand, exposure to environmental …

Dendritic and synaptic plasticity in the penumbra are important processes and are
considered to be therapeutic targets of ischemic stroke. Treadmill exercise is known to be a …

The pathogenesis of Alzheimer's disease (AD) has still not been fully elucidated, however it
is thought that the build up of amyloid plaque at least partially causes the symptoms of AD …

Fear conditioning in animals has been used extensively to model clinical anxiety disorders.
While individual animals exhibit marked differences in their propensity to undergo fear …