[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
Modulating epigenetic modifications for cancer therapy
LJ Castro-Muñoz, E Vázquez Ulloa… - Oncology …, 2023 - spandidos-publications.com
Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …
earliest genomic aberrations occurring during cancer development and are closely related …
M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma
A Du, S Li, Y Zhou, C Disoma, Y Liao, Y Zhang, Z Chen… - Molecular cancer, 2022 - Springer
Background Emerging evidence suggest the critical role of circular RNAs (circRNAs) in
disease development especially in various cancers. However, the oncogenic role of …
disease development especially in various cancers. However, the oncogenic role of …
Innovative approaches in transforming microRNAs into therapeutic tools
AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …
entire biological pathway by targeting multiple target genes. This characteristic makes …
Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer's disease
Alzheimer's disease (AD) is a multifaceted, advancing neurodegenerative illness that is
responsible for most cases of neurological impairment and dementia in the aged population …
responsible for most cases of neurological impairment and dementia in the aged population …
Trials and tribulations of MicroRNA therapeutics
AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …
particularly various cancer types, has generated significant interest in exploring their …
An easy-to-use plasmid toolset for efficient generation and benchmarking of synthetic small RNAs in bacteria
TS Köbel, R Melo Palhares, C Fromm… - ACS synthetic …, 2022 - ACS Publications
Synthetic biology approaches life from the perspective of an engineer. Standardized and de
novo design of genetic parts to subsequently build reproducible and controllable modules …
novo design of genetic parts to subsequently build reproducible and controllable modules …
Cigarette smoke-induced galectin-3 as a diagnostic biomarker and therapeutic target in lung tissue remodeling
Abstract Galectin-3 (Gal-3), a multifunctional carbohydrate-binding lectin, has emerged as a
key player in various biological processes including inflammation, cancer, cardiovascular …
key player in various biological processes including inflammation, cancer, cardiovascular …
A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
A Kotowska-Zimmer, L Przybyl, M Pewinska… - … Therapy-Nucleic Acids, 2022 - cell.com
Among the many proposed therapeutic strategies for Huntington's disease (HD), allele-
selective therapies are the most desirable but also the most challenging. RNA interference …
selective therapies are the most desirable but also the most challenging. RNA interference …
Noncoding RNAs emerging as drugs or drug targets: their chemical modification, bio-conjugation and intracellular regulation
J Wang, T Tian, X Li, Y Zhang - Molecules, 2022 - mdpi.com
With the increasing understanding of various disease-related noncoding RNAs, ncRNAs are
emerging as novel drugs and drug targets. Nucleic acid drugs based on different types of …
emerging as novel drugs and drug targets. Nucleic acid drugs based on different types of …