[HTML][HTML] Paucigranulocytic asthma: potential pathogenetic mechanisms, clinical features and therapeutic management
AI Papaioannou, E Fouka, P Ntontsi… - Journal of Personalized …, 2022 - mdpi.com
Asthma is a heterogeneous disease usually characterized by chronic airway inflammation,
in which several phenotypes have been described, related to the age of onset, symptoms …
in which several phenotypes have been described, related to the age of onset, symptoms …
Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma
Y Feng, X Liu, Y Wang, R Du, H Mao - Chinese Medical Journal, 2023 - mednexus.org
Asthma is characterized by chronic airway inflammation and airway hyper-responsiveness.
However, the differences in pathophysiology and phenotypic symptomology make a …
However, the differences in pathophysiology and phenotypic symptomology make a …
Clinical subtypes of neutrophilic asthma: a cluster analysis from Australasian Severe Asthma Network
LX He, K Deng, J Wang, X Zhang, L Wang… - The Journal of Allergy …, 2024 - Elsevier
Background Clinical heterogeneity may exist within asthma subtypes defined by
inflammatory markers. However, the heterogeneity of neutrophilic asthma (NA) remains …
inflammatory markers. However, the heterogeneity of neutrophilic asthma (NA) remains …
[HTML][HTML] Sputum metabolomic profiling reveals metabolic pathways and signatures associated with inflammatory phenotypes in patients with asthma
Y Liu, X Zhang, L Zhang, BG Oliver… - Allergy, Asthma & …, 2022 - ncbi.nlm.nih.gov
Purpose The molecular links between metabolism and inflammation that drive different
inflammatory phenotypes in asthma are poorly understood. We aimed to identify the …
inflammatory phenotypes in asthma are poorly understood. We aimed to identify the …
[HTML][HTML] Weighted gene co-expression network analysis to identify key modules and hub genes associated with paucigranulocytic asthma
M Li, W Zhu, C Wang, Y Zheng, S Sun, Y Fang… - BMC Pulmonary …, 2021 - Springer
Background Asthma is a heterogeneous disease that can be divided into four inflammatory
phenotypes: eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma …
phenotypes: eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma …
[HTML][HTML] Identification of the molecular subgroups in asthma by gene expression profiles: airway inflammation implications
M Li, W Zhu, U Saeed, S Sun, Y Fang, C Wang… - BMC Pulmonary …, 2022 - Springer
Background Asthma is a heterogeneous disease and different phenotypes based on clinical
parameters have been identified. However, the molecular subgroups of asthma defined by …
parameters have been identified. However, the molecular subgroups of asthma defined by …
Total IgE variability is associated with future asthma exacerbations: a 1-year prospective cohort study
YL Yuan, X Zhang, L Liu, G Wang, ACY Hsu… - The Journal of Allergy …, 2021 - Elsevier
Background Few prospective studies have investigated the relationship between IgE
variability and risk for asthma exacerbations (AEs). Objective To explore the relationship …
variability and risk for asthma exacerbations (AEs). Objective To explore the relationship …
Paucigranulocytic asthma: Do sputum macrophages matter?
M Olgac, SD Guler, S Demir, D Unal… - Allergy & Asthma …, 2021 - search.ebscohost.com
Background: Although paucigranulocytic asthma (PGA) is the most common phenotype of
stable asthma, its features have not been adequately studied. In this study, we aimed to …
stable asthma, its features have not been adequately studied. In this study, we aimed to …
Non‐eosinophilic asthma in nonsteroidal anti‐inflammatory drug exacerbated respiratory disease
L Mastalerz, N Celejewska‐Wójcik… - Clinical and …, 2023 - Wiley Online Library
Background The cellular inflammatory pattern of nonsteroidal anti‐inflammatory drug–
exacerbated respiratory disease (N‐ERD) is heterogeneous. However, data on the …
exacerbated respiratory disease (N‐ERD) is heterogeneous. However, data on the …
[HTML][HTML] Body Composition-Specific Asthma Phenotypes: Clinical Implications
X Zhang, K Deng, Y Yuan, L Liu, S Zhang, C Wang… - Nutrients, 2022 - mdpi.com
Background: Previous studies have indicated the limitations of body mass index for defining
disease phenotypes. The description of asthma phenotypes based on body composition …
disease phenotypes. The description of asthma phenotypes based on body composition …