This article gives an overview of recent progress in protein-protein docking and it identifies
several directions for future research. Recent results from the CAPRI blind docking …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Serratiopeptidase is the multifunctionality metalloendopeptidase extensively employed in
biopharmaceutical and industrial biotechnology. Despite its poor pH tolerance …

Aptamers are single-stranded DNA or RNA oligonucleotides generated by SELEX that
exhibit binding affinity and specificity against a wide variety of target molecules. Compared …

Docking algorithms build multimolecular assemblies based on the subunit
structures.“Unbound” docking, which starts with the free molecules and allows for …

Abstract Preclinical Research Cellular proteins are the mediators of multiple organism
functions being involved in physiological mechanisms and disease. By discovering lead …

Protein–protein binding is one of the critical events in biology, and knowledge of proteic
complexes three‐dimensional structures is of fundamental importance for the biochemical …

G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA,
and ligands able to stabilize this structure have recently been identified as potential …

Structural and physical properties of DNA provide important constraints on the binding sites
formed on surfaces of DNA-targeting proteins. Characteristics of such binding sites may form …

Caspase-independent programmed necrosis is a highly regulated cellular demise that
displays morphological and biochemical necrotic hallmarks, such as an earlier permeability …