Protein-protein interactions play a central role in all cellular processes. Insight into their
atomic architecture is therefore of paramount importance. Cryo-electron microscopy (cryo …

Serratiopeptidase is a multifaceted therapeutic enzyme renowned for its anti-inflammatory,
analgesic, anti-biofilm, fibrinolytic, and anti-edemic properties. It is vital to uncover more …

The intrinsically disordered protein p15PAF regulates DNA replication and repair by binding
to the proliferating cell nuclear antigen (PCNA) sliding clamp. We present the structure of the …

IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines
(IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical roles in host defense. To define the …

Modeling biomolecular assemblies is an important field in computational structural biology.
The inherent complexity of their energy landscape and the computational cost associated …

RNA-protein (RNP) interactions play essential roles in many biological processes, such as
regulation of co-transcriptional and post-transcriptional gene expression, RNA splicing …

We present a protein–DNA docking benchmark containing 47 unbound–unbound test cases
of which 13 are classified as easy, 22 as intermediate and 12 as difficult cases. The latter …

RNA–protein interactions are crucial for diverse biological processes. In prokaryotes, RNA–
protein interactions enable adaptive immunity through CRISPR-Cas systems. These …

Understanding the function of biomolecular complexes requires their structural analysis at
atomic resolution. To solve high-resolution structures by abinitio calculations typically data …

Xenobiotic nucleic acids (XNA) are nucleic acid analogues not present in nature that can be
used for the storage of genetic information. In vivo XNA applications could be developed into …