Cystic fibrosis (CF) is a multifactorial disease in which dysfunction of protease–antiprotease
balance plays a key role. The current CF therapy relies on dornase α, hypertonic saline, and …

Structural analysis of multi-domain protein complexes is a key challenge in current biology
and a prerequisite for understanding the molecular basis of essential cellular processes …

RecA protein is the prototypical recombinase. Members of the recombinase family can
accurately repair double strand breaks in DNA. They also provide crucial links between …

Human THAP1 is the prototype of a large family of cellular factors sharing an original THAP
zinc-finger motif responsible for DNA binding. Human THAP1 regulates endothelial cell …

Novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has claimed more
than 3.3 million lives worldwide and still counting. As per the GISAID database, the …

Modeling conformational changes in protein docking calculations is challenging. To make
the calculations tractable, most current docking algorithms typically treat proteins as rigid …

The control of red blood cell and megakaryocyte development by the regulatory protein
GATA1 is a paradigm for transcriptional regulation of gene expression in cell lineage …

Dickkopf (Dkk) proteins are antagonists of the canonical Wnt signaling pathway and are
crucial for embryonic cell fate and bone formation. Wnt antagonism of Dkk requires the …

Acetohydroxyacid synthase (AHAS) from Mycobacterium tuberculosis (Mtb) is a promising
potential drug target for an emerging class of new anti-tuberculosis agents. In this study, we …

Recent methodological and instrumental advances in solution-state nuclear magnetic
resonance have opened up the way to investigating challenging problems in structural …