The intrinsic flexibility of DNA and the difficulty of identifying its interaction surface have long
been challenges that prevented the development of efficient protein–DNA docking methods …

HP1043 is an essential orphan response regulator of Helicobacter pylori orchestrating
multiple crucial cellular processes. Classified as a member of the OmpR/PhoB family of two …

In response to a variety of environmental cues, prokaryotes can switch between a motile and
a sessile, biofilm‐forming mode of growth. The regulatory mechanisms and signaling …

Emerging SARS-CoV-2 variants with higher transmissibility and immune escape remain a
persistent threat across the globe. This is evident from the recent outbreaks of the Delta (B …

Most transcriptional regulators bind nucleotide motifs in the major groove, although some
are able to recognize molecular determinants conferred by the minor groove of DNA. Here …

Predicting the binding specificity of transcription factors is a critical step in the
characterization and computational identification and of cis-regulatory elements in genomic …

Multiple near-optimal conformations of proteinligand complexes provide a better chance for
accurate representation of biomolecular interactions, compared with a single structure. We …

Genetic variations in oncogenes can often promote uncontrolled cell proliferation by altering
the structure of the encoded protein, thereby altering its function. The PI3KCA oncogene that …

Expanded CAG trinucleotide repeats in Huntington's disease (HD) are causative for
neurotoxicity. The mutant CAG repeat RNA encodes neurotoxic polyglutamine proteins and …

The estrogen receptor α (ER-α) regulates expression of target genes implicated in
development, metabolism, and breast cancer. Calcium-dependent regulation of ER-α is …