Elastic network models (ENMs) are a useful tool for describing large scale motions in protein
systems. While they are well validated in the context of proteins, relatively little is known …

The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich
DNA sequences and controls expression of genes during embryonic morphogenesis. Here …

Excitotoxicity, depletion of energy metabolites, and ionic imbalance are the major factors
involved in neurodegeneration mediated through excitatory amino acid transporter‐2 (EAAT …

Methylation is the most common RNA modification in the three domains of life. Transfer of
the methyl group from S-adenosyl-l-methionine (AdoMet) to specific atoms of RNA …

A dogma for DNA polymerase catalysis is that the enzyme binds DNA first, followed by
MgdNTP. This mechanism contributes to the selection of correct dNTP by Watson–Crick …

Predicting DNA-binding residues from a protein three-dimensional structure is a key task of
computational structural proteomics. In the present study, based on machine learning …

Single-stranded (ss) oligonucleotide aptamers are emerging as the promising substitutes for
monoclonal antibodies because of their low production cost and good batch-to-batch …

Background Atomic details of protein-DNA complexes can provide insightful information for
better understanding of the function and binding specificity of DNA binding proteins. In …

Abstract Structure determination of homooligomeric proteins by NMR spectroscopy is difficult
due to the lack of chemical shift perturbation data, which is very effective in restricting the …

It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by
competing with endothelial nitric oxide synthase (eNOS) for their same substrate l-arginine …