Huntington's disease (HD) is a neurodegenerative disorder that is caused by an abnormal
elongation of the polyglutamine (polyQ) chain in the Huntington (Htt) protein. At present, the …

Simple Summary Infectious diseases are among the problems facing the global aquaculture
industry, particularly Vibriosis, a bacterial infection caused by the Vibrio species. In shrimp …

Helicobacter pylori (Hp) is a carcinogen that relies on Ni (II) to survive in the extreme pH
conditions of the human guts. The regulation of genes coding for Ni (II) enzymes and …

Huntington's disease is a fatal and devastating neurodegenerative genetic disorder for
which there is currently no cure. It is characterized by Huntingtin protein's mRNA transcripts …

We report here the crystal structure of a protein from Pyrococcus furiosus (Phr) that
represents the first characterized heat shock transcription factor in archaea. Phr specifically …

Members of the novel SH2-containing protein (NSP3) and Crk-associated substrate
(p130Cas) protein families form a multi-domain signalling platforms that mediate cell …

To understand cellular processes at the molecular level we need to improve our knowledge
of protein–protein interactions, from a structural, mechanistic, and energetic point of view …

TcrY, a histidine kinase, and TcrX, a response regulator, constitute a two-component system
in Mycobacterium tuberculosis. tcrX, which is expressed during iron scarcity, is instrumental …

Interfacial water molecules play an important role in many aspects of protein–DNA specificity
and recognition. Yet they have been mostly neglected in the computational modeling of …

Streptomyces griseus, a bacterium producing antibacterial drugs and featuring possible
application in phytoremediation, expresses two metal-dependent superoxide dismutase …