The rational development of new lead compounds requires good understanding of the
relationship between all the actors involved in a binding event (protein, ligand, water, metal …

NMR spectroscopy is a key technique for understanding the behaviour of proteins,
especially highly dynamic proteins that adopt multiple conformations in solution. Overall …

Myelin transcription factor 1 (MyT1/NZF2), a member of the neural zinc-finger (NZF) protein
family, is a transcription factor that plays a central role in the developing central nervous …

Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most
diverse superclasses of protein structural motifs in eukaryotes. Although our understanding …

Iron-inducible transcription of the ap65-1 gene in Trichomonas vaginalis involves at least
three Myb-like transcriptional factors (tv Myb1, tv Myb2 and tv Myb3) that differentially bind to …

RNA–LIM is a procedure that can analyze various pseudo-potentials describing the affinity
between single-stranded RNA (ssRNA) ribonucleotides and surface amino acids to produce …

The transcription regulator, tv Myb1, is the first Myb family protein identified in Trichomonas
vaginalis. Using an electrophoretic mobility shift assay, we defined the amino-acid sequence …

DNA-binding proteins such as transcription factors use DNA-binding domains (DBDs) to
bind to specific sequences in the genome to initiate many important biological functions …

Background Knowledge of protein-DNA interactions at the structural-level can provide
insights into the mechanisms of protein-DNA recognition and gene regulation. Although over …

Protein–DNA interactions are essential for many biological processes. X‐ray crystallography
can provide high‐resolution structures, but protein‐DNA complexes are difficult to crystallize …