Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …

The use of natural compounds as an alternative to synthetic molecules has become a
significant subject of interest in recent decades. Stilbenoids are a group of phenolic …

Hypoxia-inducible factor-1 alpha (HIF-1α) is overexpressed in cancer, leading to a poor
prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in …

Tau (MAPT) is a microtubule-associated protein causing common neurodegenerative
diseases or rare inherited frontotemporal lobar degenerations. Emerging evidence for non …

Background Luteolin is an active ingredient in various traditional Chinese medicines for the
treatment of multiple tumors. However, the mechanisms of its inhibitory effect on …

Osteosarcoma (OS) is a primary malignant bone tumor that occurs in children and
adolescents, and the PI3K/AKT pathway is overactivated in most OS patients. MicroRNAs …

Inflammation is an adaptive response to tissue injury, which is a critical process in order to
restore tissue functionality and homeostasis. The association between inflammation and …

Colorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United
States and the second leading cause of cancer related mortality. A therapeutic strategy used …

Purpose Osteosarcoma (OS) is a differentiation disease caused by the genetic and
epigenetic differentiation of mesenchymal stem cells into osteoblasts. OS is a common …

The complicated stepwise lysosomal degradation process known as autophagy is in charge
of destroying and eliminating damaged organelles and defective cytoplasmic components …