In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Background Psoriasis is a chronic, systemic immune‐mediated disease characterized by
development of erythematous, indurated, scaly, pruritic and often painful skin plaques …

Regulatory T (Treg) cells underlie multiple autoimmune disorders and potentialize an anti-
inflammation treatment with adoptive cell therapy. However, systemic delivery of cellular …

Numerous scientific studies in recent years have shown significant skin and gut dysbiosis
among patients with psoriasis. A significant decrease in microbiome alpha-diversity …

Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …

Introduction In the real-world APPRECIATE study (NCT02740218), most patients with
psoriasis demonstrated notable improvements on disease severity measures and reported …

Psoriasis is defined as chronic, immune-mediated disease. Regardless of the development
of new therapeutic approaches, the precise etiology of psoriasis remains unknown and …

Signal Transducer and Activator of Transcription (STAT) 3 has recently emerged as a key
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …

Psoriasis is an immune-mediated skin disorder. Imbalance of gut microbial populations has
been implicated in many diseases. We aimed to investigate whether there were differences …

The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …