IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes

R Muromoto, T Hirao, K Tawa… - International …, 2016 - academic.oup.com
In psoriasis lesions, a diverse mixture of cytokines is up-regulated that influence each other
generating a complex inflammatory situation. Although this is the case, the inhibition of IL …

Regulatory T cells restrain pathogenic T helper cells during skin inflammation

T Hartwig, P Zwicky, B Schreiner, N Yawalkar, P Cheng… - Cell reports, 2018 - cell.com
Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease
mediated by the interplay of T cells and polymorphonuclear granulocytes. Although …

Sirt1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients: A new insight into the pathogenetic mechanisms of psoriasis

M Becatti, V Barygina, A Mannucci, G Emmi… - International journal of …, 2018 - mdpi.com
Psoriasis, a multisystem chronic disease characterized by abnormal keratinocyte
proliferation, has an unclear pathogenesis where systemic inflammation and oxidative stress …

Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis

ND Loft, L Skov, L Iversen, R Gniadecki… - The …, 2018 - nature.com
Biological agents including anti-tumor necrosis factor (anti-TNF; adalimumab, infliximab,
etanercept) and anti-interleukin-12/13 (IL12/23; ustekinumab) are essential for treatment of …

Glycolipid biosurfactants in skincare applications: challenges and recommendations for future exploitation

SA Adu, MS Twigg, PJ Naughton, R Marchant… - Molecules, 2023 - mdpi.com
The 21st century has seen a substantial increase in the industrial applications of glycolipid
biosurfactant technology. The market value of the glycolipid class of molecules …

Skin microbiome: an actor in the pathogenesis of psoriasis

WM Wang, HZ Jin - Chinese Medical Journal, 2018 - journals.lww.com
Psoriasis is characterized by raised, scaly, well‑demarcated, erythematous oval plaques.[1]
Although studies have revealed that disruption of immune tolerance and excessive …

[HTML][HTML] Multiple cytokine analysis of Th1/Th2/Th9/Th17/Th22/Treg cytokine pathway for individual immune profile assessment in patients with psoriasis

A Michalak-Stoma, J Bartosińska… - … medical journal of …, 2022 - ncbi.nlm.nih.gov
Multiple Cytokine Analysis of Th1/Th2/Th9/Th17/Th22/Treg Cytokine Pathway for Individual
Immune Profile Assessment in Patients with Psoriasis - PMC Back to Top Skip to main content …

Anti-inflammation activity of brazilin in TNF-α induced human psoriasis dermatitis skin model

DH Choi, HS Hwang - Applied Biological Chemistry, 2019 - Springer
Psoriasis is a chronic inflammatory skin disease that causes erythema, scale, and invasion
due to excessive proliferation of keratinocyte and vascular deformation of the upper part of …

Pharmacology of orismilast, a potent and selective PDE4 inhibitor

JI Silverberg, LE French, RB Warren… - Journal of the …, 2023 - Wiley Online Library
Background There remains an unmet need for oral medications that are safe and efficacious
for long‐term management of chronic inflammatory skin diseases (CISD). Inhibition of …

Efficacy and safety of different formulations of calcipotriol/betamethasone dipropionate in psoriasis: gel, foam, and ointment

L Rudnicka, M Olszewska, M Goldust… - Journal of Clinical …, 2021 - mdpi.com
Preparations containing calcipotriol combined with betamethasone dipropionate (in the
forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This …