The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

Technology insight: Plant-derived vesicles—How far from the clinical biotherapeutics and therapeutic drug carriers?

M Cong, S Tan, S Li, L Gao, L Huang, HG Zhang… - Advanced drug delivery …, 2022 - Elsevier
Within the past decades, extracellular vesicles (EVs) have emerged as important mediators
of intercellular communication in both prokaryotes and higher eukaryotes to regulate a …

Overview and update on extracellular vesicles: considerations on exosomes and their application in modern medicine

MA Di Bella - Biology, 2022 - mdpi.com
Simple Summary Exosomes are a subpopulation of extracellular vesicles, nanosized
particles, lipid bilayer-enclosed, naturally secreted from cells after the fusion of intracellular …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics

S Wang, B Lei, E Zhang, P Gong, J Gu… - International Journal …, 2022 - Taylor & Francis
Inflammation is a beneficial and physiological process, but there are a number of
inflammatory diseases which have detrimental effects on the body. In addition, the drugs …

β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis

S Chen, M Zhang, J Li, J Huang, S Zhou… - Journal of …, 2022 - Wiley Online Library
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …

p53 deacetylation alleviates sepsis-induced acute kidney injury by promoting autophagy

M Sun, J Li, L Mao, J Wu, Z Deng, M He, S An… - Frontiers in …, 2021 - frontiersin.org
Recent studies have shown that autophagy upregulation can attenuate sepsis-induced
acute kidney injury (SAKI). The tumor suppressor p53 has emerged as an autophagy …

Mesenchymal stem cell-derived extracellular vesicles attenuate tPA-induced blood–brain barrier disruption in murine ischemic stroke models

L Qiu, Y Cai, Y Geng, X Yao, L Wang, H Cao, X Zhang… - Acta Biomaterialia, 2022 - Elsevier
Intracerebral hemorrhage following blood–brain barrier (BBB) disruption resulting from
thrombolysis of ischemic stroke with tissue plasminogen activator (tPA) remains a critical …

Renal endothelial cell‐targeted extracellular vesicles protect the kidney from ischemic injury

K Zhang, R Li, X Chen, H Yan, H Li, X Zhao… - Advanced …, 2023 - Wiley Online Library
Endothelial cell injury plays a critical part in ischemic acute kidney injury (AKI) and
participates in the progression of AKI. Targeting renal endothelial cell therapy may …

[HTML][HTML] Human bone marrow mesenchymal stem cell-derived extracellular vesicles inhibit shoulder stiffness via let-7a/Tgfbr1 axis

Z Luo, Y Sun, B Qi, J Lin, Y Chen, Y Xu, J Chen - Bioactive Materials, 2022 - Elsevier
Shoulder stiffness (SS) is a common shoulder disease characterized by increasing pain and
limited range of motion. SS is considered to be an inflammatory and fibrotic disorder …