Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for
about 90% of cancer deaths. Although cancer survival rate has been significantly improved …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Metastasis is the major driver of death in patients with cancer. Invasion of surrounding
tissues and metastasis have been proposed to initiate following loss of the intercellular …

Numerous publications have stated that metastases are responsible for 90% of cancer
deaths, but data underlying this assertion has been lacking. Our objective was to determine …

The concept that the pattern of metastatic spread of cancer is not random and that cancer
cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven …

Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently
discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the …

Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum,
trabecular bone, adipose tissue, synovium, skeletal muscle and deciduous teeth. These …

A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …

Background The stromal microenvironment and particularly the macrophage component of
primary tumors influence their malignant potential. However, at the metastatic site the role of …

New blood vessel formation (angiogenesis) is fundamental to tumor growth, invasion, and
metastatic dissemination. The vascular endothelial growth factor (VEGF) signaling pathway …