Neurodegeneration and inflammation—an interesting interplay in Parkinson's disease

C Marogianni, M Sokratous, E Dardiotis… - International journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …

Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson's disease: roads to biomarker discovery

A Picca, F Guerra, R Calvani, R Romano… - Biomolecules, 2021 - mdpi.com
Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …

The role of genetics in Parkinson's disease: a large cohort study in Chinese mainland population

Y Zhao, L Qin, H Pan, Z Liu, L Jiang, Y He, Q Zeng… - Brain, 2020 - academic.oup.com
This study aimed to determine the mutational spectrum of familial Parkinson's disease and
sporadic early-onset Parkinson's disease (sEOPD) in a mainland Chinese population and …

Blinded RT‐QuIC analysis of α‐Synuclein biomarker in skin tissue from Parkinson's disease patients

S Manne, N Kondru, H Jin, GE Serrano… - Movement …, 2020 - Wiley Online Library
Background An unmet clinical need in Parkinson's disease (PD) is to identify biomarkers for
diagnosis, preferably in peripherally accessible tissues such as skin. Immunohistochemical …

Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Lipid and lipid raft alteration in aging and neurodegenerative diseases: a window for the development of new biomarkers

F Mesa-Herrera, L Taoro-González… - International journal of …, 2019 - mdpi.com
Lipids in the brain are major components playing structural functions as well as
physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic …

Probiotics for Parkinson's disease

P Gazerani - International journal of molecular sciences, 2019 - mdpi.com
Parkinson's disease (PD) is a complex neurological disorder classically characterized by
impairments in motor system function associated with loss of dopaminergic neurons in the …

[HTML][HTML] Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease

E Kip, LC Parr-Brownlie - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

Biomarkers of neurodegenerative diseases: biology, taxonomy, clinical relevance, and current research status

D Koníčková, K Menšíková, L Tučková, E Hényková… - Biomedicines, 2022 - mdpi.com
The understanding of neurodegenerative diseases, traditionally considered to be well-
defined entities with distinguishable clinical phenotypes, has undergone a major shift over …

Clinical and imaging markers of prodromal Parkinson's disease

E Hustad, JO Aasly - Frontiers in neurology, 2020 - frontiersin.org
The diagnosis of Parkinson's disease (PD) relies on the clinical effects of dopamine
deficiency, including bradykinesia, rigidity and tremor, usually manifesting asymmetrically …