Supported by a usage history that predates written records and the perception that “natural”
ensures safety, herbal products have increasingly been incorporated into Western health …

Extracts of milk thistle have been recognized for centuries as “liver tonics” and are well-
known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring …

A new type of interaction in which fruit juices diminish oral drug bioavailability through
inhibition of uptake transport is the focus of this review. The discovery was based on an …

Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …

Food–drug interaction studies are critical to evaluate appropriate dosing, timing, and
formulation of new drug candidates. These interactions often reflect prandial-associated …

Intestinal metabolism can limit oral bioavailability of drugs and increase the risk of drug
interactions. It is therefore important to be able to predict and quantify it in drug discovery …

CYP3A is one of the most important drug-metabolizing enzymes, determining the first-pass
metabolism, oral bioavailability, and elimination of many drugs. It is also an important …

Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs)
that mediate the uptake of a diverse group of drugs and endogenous compounds into cells …

The effects of green tea catechins on the main drug-metabolizing enzymatic system,
cytochrome P450 (CYP), have not been fully elucidated. The objective of the present study …

Food ingestion affects the oral absorption of many drugs in humans. In this review article, we
summarize the physiological factors in the gastrointestinal (GI) tract that affect the in vivo …