A role for an HTLV-1 vaccine?

L Ratner - Frontiers in immunology, 2022 - frontiersin.org
HTLV-1 is a global infection with 5-20 million infected individuals. Although only a minority of
infected individuals develop myelopathy, lymphoproliferative malignancy, or inflammatory …

The slowdown of new infections by human retroviruses has reached a plateau in Spain

C de Mendoza, P Carrizo, S Sauleda… - Journal of medical …, 2023 - Wiley Online Library
The 2022 annual meeting of the HTLV & HIV‐2 Spanish Network was held in Madrid on
December 14. We summarize here the main information presented and discussed at the …

High human T-cell leukemia virus type 1c proviral loads are associated with diabetes and chronic kidney disease: results of a cross-sectional community survey in …

MR Talukder, R Woodman, H Pham… - Clinical Infectious …, 2023 - academic.oup.com
Background A link between chronic inflammation and several noncommunicable diseases
(NCDs) has been established. Although chronic infection with the human T-cell leukemia …

Human T cell lymphotropic virus type 1 global prevalence associated with the human development index: systematic review with meta-analysis

GCL Sampaio, JR Ribeiro, CN de Almeida… - AIDS Research and …, 2023 - liebertpub.com
In 2012, the number of people infected with human T cell lymphotropic virus type 1 (HTLV-1)
was estimated to be 10 million worldwide. Prevalence varies according to geographic …

HTLV-1 transmission and HIV pre-exposure prophylaxis: a scoping review

D Bradshaw, GP Taylor - Frontiers in Medicine, 2022 - frontiersin.org
HIV pre-exposure prophylaxis (HIV-PrEP) is effective in reducing the likelihood of HIV
acquisition in HIV-negative people at high risk of exposure. Guidelines recommend testing …

A qualitative study exploring perceptions to the human T cell leukaemia virus type 1 in central Australia: Barriers to preventing transmission in a remote aboriginal …

F Fowler, L Einsiedel - Frontiers in Medicine, 2022 - frontiersin.org
Background Central Australia has the highest recorded prevalence of infection with the
human T cell leukaemia virus type 1 (HTLV-1) worldwide. Each of the clinical diseases …

HTLV-1 Proliferation after CD8+ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques

M Nakamura-Hoshi, T Nomura, M Nishizawa… - Microbiology …, 2023 - Am Soc Microbiol
HTLV-1 can cause serious diseases such as adult T-cell leukemia (ATL) in humans after
chronic asymptomatic latent infection with substantial proviral load. Proviruses are …

Human T-lymphotropic virus type 1 and antiretroviral therapy: practical considerations for pre-exposure and post-exposure prophylaxis, transmission prevention, and …

JS O'Donnell, N Jaberolansar, KJ Chappell - The Lancet Microbe, 2024 - thelancet.com
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with substantial risk
of secondary (often life-threatening) disease for the estimated 10 million to 20 million people …

The Association between Diabetes and Human T-Cell Leukaemia Virus Type-1 (HTLV-1) with Strongyloides stercoralis: Results of a Community-Based, Cross …

MR Talukder, H Pham, R Woodman, K Wilson… - International Journal of …, 2022 - mdpi.com
In central Australia, an area that is endemic for the human T-cell leukaemia virus type-1
(HTLV-1), the prevalence of Strongyloides stercoralis and its association with other health …

Prophylactic vaccination inducing anti-Env antibodies can result in protection against HTLV-1 challenge in macaques

M Nakamura-Hoshi, H Ishii, T Nomura, M Nishizawa… - Molecular Therapy, 2024 - cell.com
Human T cell leukemia/T-lymphotropic virus type 1 (HTLV-1) infection occurs by cell-to-cell
transmission and can induce fatal adult T cell leukemia. Vaccine development is critical for …