Evolution of the human pathogenic lifestyle in fungi

A Rokas - Nature Microbiology, 2022 - nature.com
Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Legionnaires' Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella

S Mondino, S Schmidt, M Rolando… - Annual Review of …, 2020 - annualreviews.org
Legionella species are environmental gram-negative bacteria able to cause a severe form of
pneumonia in humans known as Legionnaires' disease. Since the identification of …

Biosynthesis, evolution and ecology of microbial terpenoids

M Avalos, P Garbeva, L Vader, GP van Wezel… - Natural Product …, 2022 - pubs.rsc.org
Covering: through June 2021 Terpenoids are the largest class of natural products
recognised to date. While mostly known to humans as bioactive plant metabolites and part of …

Immunity to invasive fungal diseases

A Casadevall - Annual review of immunology, 2022 - annualreviews.org
Invasive fungal diseases are rare in individuals with intact immunity. This, together with the
fact that there are only a few species that account for most mycotic diseases, implies a …

The consequences of our changing environment on life threatening and debilitating fungal diseases in humans

N Van Rhijn, M Bromley - Journal of Fungi, 2021 - mdpi.com
Human activities have significantly impacted the environment and are changing our climate
in ways that will have major consequences for ourselves, and endanger animal, plant and …

Environmental Candida auris and the global warming emergence hypothesis

A Casadevall, DP Kontoyiannis, V Robert - MBio, 2021 - Am Soc Microbiol
Global warming was proposed to be a contributing cause for the nearly simultaneous
emergence of different clades of Candida auris as a nosocomial pathogen in different …

Emergence and evolution of virulence in human pathogenic fungi

S Siscar-Lewin, B Hube, S Brunke - Trends in microbiology, 2022 - cell.com
One billion people worldwide are affected by fungal pathogens, of which 1.6 million
succumb to fungal infections per year. This review discusses the emergence and evolution …

A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence

H Itabangi, PCS Sephton-Clark, DP Tamayo, X Zhou… - Current biology, 2022 - cell.com
Opportunistic infections by environmental fungi are a growing clinical problem, driven by an
increasing population of people with immunocompromising conditions. Spores of the …

Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence

RP Baker, A Casadevall - Nature communications, 2023 - nature.com
The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications

X Guruceaga, U Perez-Cuesta, A Abad-Diaz de Cerio… - Toxins, 2019 - mdpi.com
Fumagillin is a mycotoxin produced, above all, by the saprophytic filamentous fungus
Aspergillus fumigatus. This mold is an opportunistic pathogen that can cause invasive …