Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …

Mild traumatic brain injury (mTBI) is an important public health issue, as it can lead to long-
term neurological symptoms and risk of neurodegenerative disease. The pathophysiological …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …

The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …

The severity of Alzheimer9s disease (AD) progression involves a complex interplay of
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …

In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …

Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a
hallmark of cancer that profoundly influences the development and progression of prostate …

Abstract The last decade (2013–2023) has seen unprecedented successes in the clinical
translation of therapeutic antisense oligonucleotides (ASOs). Eight such molecules have …

TIMMDC1 encodes the T ranslocase of I nner M itochondrial M embrane D omain-C
ontaining protein 1 (TIMMDC1) subunit of complex I of the electron transport chain …