Pathophysiology of systemic sclerosis: current understanding and new insights
ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …
The immunology of fibrosis
G Wick, C Grundtman, C Mayerl… - Annual review of …, 2013 - annualreviews.org
Fibrosis is the production of excessive amounts of connective tissue, ie, scar formation, in
the course of reactive and reparative processes. Fibrosis develops as a consequence of …
the course of reactive and reparative processes. Fibrosis develops as a consequence of …
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …
Endoglin: beyond the endothelium
MJA Schoonderwoerd, MJTH Goumans… - Biomolecules, 2020 - mdpi.com
Endoglin, a type-III accessory receptor for the Transforming Growth Factor (TGF)-β
superfamily pathway, is known for its crucial role during angiogenesis. Extensive work has …
superfamily pathway, is known for its crucial role during angiogenesis. Extensive work has …
The yin and yang of IL-17 in systemic sclerosis
L Wei, D Abraham, V Ong - Frontiers in Immunology, 2022 - frontiersin.org
IL-17 (IL-17A) is a pro-inflammatory cytokine produced by a sub-set of T helper cells termed
Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role …
Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role …
T follicular helper–like cells contribute to skin fibrosis
DK Taylor, N Mittereder, E Kuta, T Delaney… - Science translational …, 2018 - science.org
Systemic sclerosis (SSc) is a debilitating inflammatory and fibrotic disease that affects the
skin and internal organs. Although the pathophysiology of SSc remains poorly …
skin and internal organs. Although the pathophysiology of SSc remains poorly …
Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the …
Low vitamin D serum concentrations have been reported in several autoimmune conditions.
The study's aim was to explore such a relationship in a large multinational population of …
The study's aim was to explore such a relationship in a large multinational population of …
Adipose-derived mesenchymal stem cells in autoimmune disorders: state of the art and perspectives for systemic sclerosis
Mesenchymal stromal/stem cells (MSC) are non-hematopoietic multipotent progenitor cells,
first described in bone marrow in the middle of last century. Since then, MSC have been the …
first described in bone marrow in the middle of last century. Since then, MSC have been the …
Vascular leaking, a pivotal and early pathogenetic event in systemic sclerosis: should the door be closed?
The early phase of systemic sclerosis (SSc) presents edema as one of the main features:
this is clinically evident in the digital swelling (puffy fingers) as well as in the edematous skin …
this is clinically evident in the digital swelling (puffy fingers) as well as in the edematous skin …
pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis
Background Gastrointestinal tract (GIT) involvement is a common cause of debilitating
symptoms in patients with systemic sclerosis (SSc). There are no disease modifying …
symptoms in patients with systemic sclerosis (SSc). There are no disease modifying …