Chimerism analysis for clinicians: a review of the literature and worldwide practices

AG Blouin, M Askar - Bone marrow transplantation, 2022 - nature.com
This review highlights literature pertinent to chimerism analysis in the context of
hematopoietic cell transplantation (HCT). We also conducted a survey of testing practices of …

How I treat measurable (minimal) residual disease in acute leukemia after allogeneic hematopoietic cell transplantation

A Spyridonidis - Blood, The Journal of the American Society of …, 2020 - ashpublications.org
Although allogeneic hematopoietic cell transplantation (allo-HCT) is currently the standard
curative treatment of acute leukemia, relapse remains unacceptably high. Measurable …

Short tandem repeats (STRs) as biomarkers for the quantitative follow-up of chimerism after stem cell transplantation: methodological considerations and clinical …

A Navarro-Bailón, D Carbonell, A Escudero, M Chicano… - Genes, 2020 - mdpi.com
Chimerism refers to the relative proportion of donor and recipient DNA after hematopoietic
stem cell transplantation (HSCT) and its quantitative follow-up is of great clinical utility in this …

Optimizing transplant approaches and post-transplant strategies for patients with acute myeloid leukemia

J Loke, H Vyas, C Craddock - Frontiers in Oncology, 2021 - frontiersin.org
Acute Myeloid Leukemia (AML) is the commonest indication for allogeneic stem cell
transplantation (allo-SCT) worldwide. The increasingly important role of allo-SCT in the …

Droplet digital PCR for the simultaneous analysis of minimal residual disease and hematopoietic chimerism after allogeneic cell transplantation

M Waterhouse, D Pfeifer, J Duque-Afonso… - Clinical Chemistry and …, 2019 - degruyter.com
Background Minimal residual disease (MRD) and hematopoietic chimerism testing
influences clinical decision and therapeutic intervention in patients after allogeneic stem cell …

Lineage-specific early complete donor chimerism and risk of relapse after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia

H Lindahl, S Vonlanthen, D Valentini… - Bone Marrow …, 2022 - nature.com
Recipient–donor chimerism is routinely analyzed after allogeneic hematopoietic stem cell
transplantation (HSCT) to monitor engraftment and graft rejection. For malignancies …

[HTML][HTML] Personalized chimerism test that uses selection of short tandem repeat or quantitative PCR depending on patient's chimerism status

J Tyler, L Kumer, C Fisher, H Casey, H Shike - The Journal of Molecular …, 2019 - Elsevier
Chimerism testing is used to monitor engraftment and risk of relapse after allogeneic
hematopoietic stem cell transplantation for hematologic malignancies. Although short …

Current trends in applications of circulatory microchimerism detection in transplantation

H Andrikovics, Z Őrfi, N Meggyesi, A Bors… - International Journal of …, 2019 - mdpi.com
Primarily due to recent advances of detection techniques, microchimerism (the proportion of
minor variant population is below 1%) has recently gained increasing attention in the field of …

Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI

CR Schultze-Florey, L Kuhlmann, S Raha… - Blood …, 2021 - ashpublications.org
Donor lymphocyte infusion (DLI) is a standard of care for relapse of acute myeloid leukemia
after allogeneic hematopoietic stem cell transplantation. Currently it is poorly understood …

Chimerism Testing by Next Generation Sequencing for Detection of Engraftment and Early Disease Relapse in Allogeneic Hematopoietic Cell Transplantation and an …

A Liacini, G Tripathi, A McCollick, C Gravante… - International Journal of …, 2023 - mdpi.com
Chimerism monitoring after allogenic Hematopoietic Cell Transplantation (allo-HCT) is
critical to determine how well donor cells have engrafted and to detect relapse for early …