The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
PM Exconde, C Hernandez-Chavez, CM Bourne… - Cell reports, 2023 - cell.com
Inflammasomes are multiprotein signaling complexes that activate the innate immune
system. Canonical inflammasomes recruit and activate caspase-1, which then cleaves and …
system. Canonical inflammasomes recruit and activate caspase-1, which then cleaves and …
[HTML][HTML] The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases
PM Exconde, C Hernandez-Chavez, MB Bray… - BioRxiv, 2023 - ncbi.nlm.nih.gov
The mammalian innate immune system uses germline-encoded cytosolic pattern-
recognition receptors (PRRs) to detect intracellular danger signals. At least six of these …
recognition receptors (PRRs) to detect intracellular danger signals. At least six of these …