The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

It remains unclear how obesity worsens treatment outcomes in patients with pancreatic
ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and …

Background Obesity and the metabolic syndrome are increasingly prevalent in society and
their complications and response to treatment exhibit sexual dimorphism. Mouse models of …

Increases in adipocyte volume and tissue mass due to obesity can result in inflammation,
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

Diabetes was the first disease state where evidence emerged for increased formation of
methylglyoxal. Metabolism of methylglyoxal by the glyoxalase system has been linked to the …

Brown adipose tissue (BAT) is increasingly recognized as the major therapeutic target to
promote energy expenditure and ameliorate diverse metabolic complications. There is a …

Obesity is associated with a high prevalence of mood disorders and cognitive dysfunctions
in addition to being a significant risk factor for important health complications such as …

Neuropsychiatric symptoms are frequent in obesity. In addition to their substantial economic
and health impact, these symptoms significantly interfere with the quality of life and social …