CryoDRGN-ET: deep reconstructing generative networks for visualizing dynamic biomolecules inside cells
Advances in cryo-electron tomography (cryo-ET) have produced new opportunities to
visualize the structures of dynamic macromolecules in native cellular environments. While …
visualize the structures of dynamic macromolecules in native cellular environments. While …
Building up complexity in structural biology studies
E Nogales - Nature Structural & Molecular Biology, 2024 - nature.com
Macromolecules are involved in myriads of interactions that regulate their cellular function.
While years of structural biology progress was built by reducing this complexity, a molecular …
While years of structural biology progress was built by reducing this complexity, a molecular …
Unraveling the ultrastructure and dynamics of autophagic vesicles: Insights from advanced imaging techniques
T Jiang, C Ma, H Chen - FASEB BioAdvances, 2024 - Wiley Online Library
Autophagy, an intracellular self‐degradation process, is governed by a complex interplay of
signaling pathways and interactions between proteins and organelles. Its fundamental …
signaling pathways and interactions between proteins and organelles. Its fundamental …
In-cell architecture of the mitochondrial respiratory chain
F Waltz, RD Righetto, X Zhang, R Kelley, M Obr… - bioRxiv, 2024 - biorxiv.org
Mitochondria produce energy through oxidative phosphorylation, carried out by five
membrane-bound complexes collectively known as the respiratory chain. These complexes …
membrane-bound complexes collectively known as the respiratory chain. These complexes …
Revealing biomolecular structure and motion with neural ab initio cryo-EM reconstruction
Proteins and other biomolecules form dynamic macromolecular machines that are tightly
orchestrated to move, bind, and perform chemistry. Cryo-electron microscopy (cryo-EM) can …
orchestrated to move, bind, and perform chemistry. Cryo-electron microscopy (cryo-EM) can …
CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis
L Wu, J Wang, Y Wang, J Yang, Y Yao, D Huang, Y Hu… - bioRxiv, 2024 - biorxiv.org
The intricate orchestration of lipid production, storage, and mobilization is vital for cellular
and systemic homeostasis1, 2. Dysfunctional plasma lipid control represents the major risk …
and systemic homeostasis1, 2. Dysfunctional plasma lipid control represents the major risk …
biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus
Recent advances in molecular and cell biology and imaging have unprecedentedly enabled
multi-scale structure-functional studies of entire metabolic pathways from atomic to …
multi-scale structure-functional studies of entire metabolic pathways from atomic to …
Tools for Analysis of Large-scale Cryo-EM and Cryo-ET Data
R Raghu - 2024 - search.proquest.com
Cryo-electron microscopy (cryo-EM) is a powerful technique for visualizing the structure and
dynamics of macromolecules in near-physiological conditions. Owing to cryo-EM's ability to …
dynamics of macromolecules in near-physiological conditions. Owing to cryo-EM's ability to …
[PDF][PDF] Machine Learning Approaches for Automated Image Analysis in Cell Biology and Structural Biology
When it comes to studying microscopic picture data in cell biology research, robotic
processing of information and machine learning approaches are crucial, as discussed in the …
processing of information and machine learning approaches are crucial, as discussed in the …