The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Antimicrobial peptides (AMPs) are essential elements of thehost defense system.
Characterized by heterogenous structures and broad‐spectrumaction, they are promising …

Lipid nanoparticles (LNPs) are a leading biomimetic drug delivery platform due to their
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …

Antimicrobial peptides (AMPs) offer significant hope in the fight against antibiotic resistance.
Operating via a mechanism different from that of antibiotics, they target the microbial …

Cell entry is one of the common prerequisites for nanomaterial applications. Despite
extensive studies on a homogeneous group of nanoparticles (NPs), fewer studies have …

Expression of mobile colistin resistance gene mcr-1 results in the addition of
phosphoethanolamine (pEtN) to the lipid A headgroup in the bacterial outer membrane (OM) …

The cell membrane permeabilization ability of immune defense antimicrobial peptides
(AMPs) is widely applied in biomedicine. Although the mechanisms of peptide–membrane …

Abstract Transportan 10 (TP10) is a 21-residue, cationic, α-helical cell-penetrating peptide
that can be used as a delivery vector for various bioactive molecules. Based on recent …

A real-time and molecule-level monitoring of the interfacial dynamic interactions between
molecules and a cell membrane is of vital importance. Herein, taking TAT, one of the most …

The antimicrobial peptide double cooperative effect, where the mixture of two major
antimicrobial peptides LL-37 and HNP1 kills bacteria more efficiently while minimizing the …