Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …

Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …

The distinctive differentiated states of the CD4+ T helper cells are determined by the set of
transcription factors and the genes transcribed by the transcription factors. In vitro induction …

Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Accumulating evidence attests to the important roles of both macrophages and chemokines
in angiogenesis. Tumor-associated macrophages or TAMS constitute the major fraction of …

CXC chemokines are involved in chemotaxis, regulation of cell growth, induction of
apoptosis and modulation of angiostatic effects. CXCL9, CXCL10, CXCL11, CXCL4 and its …

Chemokines are chemotactic cytokines which recruit leukocytes to inflammatory sites. They
also affect tumor development and metastasis by acting as growth factor, by attracting pro-or …

Chemokines control the migratory patterns and positioning of immune cells to organize
immune responses to pathogens. However, many chemokines have been associated with …