Breast cancers with positive expression of Estrogen Receptor (ER+) are treated with anti-
hormone/endocrine therapy which targets the activity of the receptor, the half-life of the …

A comprehensive summary of more than 450 estrogenic chemicals including estrogenic
endocrine disruptors is provided here to understand the complex and profound impact of …

Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally
isolated from prostate cancer cell lines derived from a single patient, are detected in normal …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Breast cancer is a heterogeneous disease manifesting diversity at the molecular,
histological and clinical level. The development of breast cancer classification was centered …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

Estrogens regulate various normal and pathophysiological processes including cancers.
Cellular signaling by estrogens is mediated by estrogen receptor α (ERα) and β (ERβ) …

Estrogen signaling pathways, because of their central role in regulating the growth and
survival of breast tumor cells, have been identified as suitable and efficient targets for cancer …

Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …