Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more …

Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes
characterized by progressive executive, behavioural and language dysfunction. The various …

With an increasingly aging population, health care providers will treat a higher number of
patients with cognitive impairment. Identifying cognitive impairment and intervening early …

The use of iPSC derived brain organoid models to study neurodegenerative disease has
been hampered by a lack of systems that accurately and expeditiously recapitulate …

The blood-brain barrier (BBB) is composed of a layer of endothelial cells that is interspersed
with a series of tight junctions and characterized by the absence of fenestrations. The …

Mental disorders represent common brain diseases characterized by substantial
impairments of social and cognitive functions. The neurobiological causes and mechanisms …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Aging is a risk factor for major central nervous system (CNS) disorders. More specifically,
aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact …

Since the initial identification of TMEM106B as a risk factor for frontotemporal lobar
degeneration (FTLD), multiple genetic studies have found TMEM106B variants to modulate …

In this review, the authors explored the clinical features of frontotemporal dementia (FTD),
focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy …