Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy

C Bailly - Chemical reviews, 2012 - ACS Publications
1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …

[HTML][HTML] Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

GQ Chen, HY Guo, ZS Quan, QK Shen, X Li, T Luan - Molecules, 2023 - mdpi.com
Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Synthesis of novel fluorescent benzo [a] pyrano [2, 3-c] phenazine and benzo [a] chromeno [2, 3-c] phenazine derivatives via facile four-component domino protocol

P Saluja, A Chaudhary, JM Khurana - Tetrahedron letters, 2014 - Elsevier
An efficient and practical route to novel fluorescent benzo [a] pyrano [2, 3-c] phenazine
framework has been developed by one-pot, four-component reaction of 2 …

Discovery and structure–activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells

HI Ciftci, N Bayrak, H Yıldırım, M Yıldız… - Archiv der …, 2019 - Wiley Online Library
Abstract Two series of amino‐1, 4‐benzoquinones (AQ1–18) based on the structural
analogs of plastoquinones were synthesized and the structure–activity relationship against …

One-Pot Synthesis of Spiro-isobenzofuran Compounds via the Sequential Condensation/Oxidation Reaction of Ninhydrin with 4-Amino-1,2-naphthoquinones/2 …

SH Mousavi, MR Mohammadizadeh, Z Roshan… - ACS …, 2020 - ACS Publications
A one-pot route for the synthesis of spiro-isobenzofuran compounds was developed via the
condensation reaction of ninhydrin with 4-amino-1, 2-naphthoquinones or 2-amino-1, 4 …

Synthesis and cytotoxicity of 2-phenylquinazolin-4 (3H)-one derivatives

HK Rhee, JH Yoo, E Lee, YJ Kwon, HR Seo… - European journal of …, 2011 - Elsevier
Thirty 2-phenylquinazolin-4 (3H)-one derivatives were prepared and their cytotoxic activities
were tested in five human tumor cell lines. Some compounds (5e, 5k, 5t, 6c and 6f) showed …

Caffeine catalyzed green synthesis of novel benzo [a][1, 3] oxazino [6, 5-c] phenazines via a one-pot multi-component sequential protocol in a basic ionic liquid

R Mohebat, A Yazdani-Elah-Abadi - Chinese Chemical Letters, 2017 - Elsevier
Caffeine was applied as a green and natural catalyst for the one-pot, four-component
sequential condensation between 2-hydroxy-1, 4-naphthoquinone, aromatic 1, 2-diamines …

DABCO-catalyzed multi-component domino reactions for green and efficient synthesis of novel 3-oxo-3H-benzo [a] pyrano [2, 3-c] phenazine-1-carboxylate and 3-(5 …

R Mohebat, A Yazdani-Elah-Abadi… - Chinese Chemical …, 2017 - Elsevier
An efficient, convenient and environmentally benign procedure for the synthesis of novel 3-
oxo-3H-benzo [a] pyrano [2, 3-c] phenazine-1-carboxylate and 3-(5-hydroxybenzo [a] …

Synthesis, antiproliferative activity and molecular docking studies of novel benzo [a] pyrano-[2, 3-c] phenazine derivatives

P Nagaraju, PN Reddy, P Padmaja, VG Ugale - Chemical Data Collections, 2020 - Elsevier
A new one pot three-component reaction for the synthesis of benzo [a] pyrano-[2, 3-c]
phenazine derivatives has been developed. The synthesis was achieved by reacting benzo …

Microwave-assisted and L-proline catalysed domino cyclisation in an aqueous medium: a rapid, highly efficient and green synthesis of benzo [a] phenazine annulated …

A Yazdani-Elah-Abadi, R Mohebat… - Journal of Chemical …, 2016 - journals.sagepub.com
A highly efficient one-pot, two-step microwave-assisted procedure was applied for the rapid
and green synthesis of benzo [a] phenazine annulated heterocyclic ring systems from the …