Slc6a14 and Slc38a5 drive the glutaminolysis and serine–Glycine–One-Carbon pathways in cancer

T Sniegowski, K Korac, YD Bhutia, V Ganapathy - Pharmaceuticals, 2021 - mdpi.com
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions
that are reprogramed and upregulated in cancer; these pathways are involved in supporting …

[HTML][HTML] Amino Acid Transporter SLC6A14 (ATB0,+) – A Target in Combined Anti-cancer Therapy

KA Nałęcz - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Cancer cells are characterized by quick growth and proliferation, demanding constant
supply of various nutrients. Several plasma membrane transporters delivering such …

[HTML][HTML] HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferation and metastasis

EB Chen, X Qin, K Peng, Q Li, C Tang, YC Wei… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Gastric cancer (GC) is a common disease globally with high mortality rate. It is therefore
necessary to develop novel therapies targeting specific events in the pathogenesis of GC …

TMC4 is a novel chloride channel involved in high-concentration salt taste sensation

Y Kasahara, M Narukawa, Y Ishimaru, S Kanda… - The Journal of …, 2021 - Springer
Abstract “Salty taste” sensation is evoked when sodium and chloride ions are present
together in the oral cavity. The presence of an epithelial cation channel that receives Na+ …

[HTML][HTML] Early diagnosis of pancreatic ductal adenocarcinoma by combining relative expression orderings with machine-learning method

ZM Zhang, JS Wang, H Zulfiqar, H Lv… - Frontiers in Cell and …, 2020 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer deeply
affecting human health. Diagnosing early-stage PDAC is the key point to PDAC patients' …

Development and clinical validation of a novel 9-gene prognostic model based on multi-omics in pancreatic adenocarcinoma

D Xu, Y Wang, X Liu, K Zhou, J Wu, J Chen… - Pharmacological …, 2021 - Elsevier
The prognoses of patients with pancreatic adenocarcinoma (PAAD) remain poor due to the
lack of biomarkers for early diagnosis and effective prognosis prediction. RNA sequencing …

Robust identification of common genomic biomarkers from multiple gene expression profiles for the prognosis, diagnosis, and therapies of pancreatic cancer

MB Hossen, MA Islam, MS Reza, MK Kibria… - Computers in Biology …, 2023 - Elsevier
Pancreatic cancer (PC) is one of the leading causes of cancer-related death globally. So,
identification of potential molecular signatures is required for diagnosis, prognosis, and …

Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer

T Liang, X Wu, L Wang, Z Ni, Y Fan, P Wu… - … -Research and Practice, 2023 - Elsevier
Purpose To identify specific novel genes that could be used as diagnostic and prognostic
factors in papillary thyroid carcinoma (PTC). Methods Screening of differential genes by …

Exosome‐mediated lncRNA SNHG11 regulates angiogenesis in pancreatic carcinoma through miR‐324‐3p/VEGFA axis

X Fang, Y Cai, Y Xu, H Zhang - Cell Biology International, 2022 - Wiley Online Library
Pancreatic carcinoma (PC) is one of the most common and deadly human malignancies
worldwide. LncRNAs play significant roles in the occurrence and development of various …

Immune cell modulation of the extracellular matrix contributes to the pathogenesis of pancreatic cancer

RS Ahmad, TD Eubank, S Lukomski, BA Boone - Biomolecules, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a five-year
survival rate of only 9%. PDAC is characterized by a dense, fibrotic stroma composed of …