Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

A Agustí, E Melen, DL DeMeo… - The Lancet …, 2022 - thelancet.com
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …

[HTML][HTML] Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

The social origins of obesity within and across generations

E Hemmingsson, P Nowicka, S Ulijaszek… - Obesity …, 2023 - Wiley Online Library
We propose a model for obesity development that traces a considerable part of its origins to
the social domain (mainly different forms of prolonged social adversity), both within and …

[HTML][HTML] The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

VWV Jaddoe, JF Felix, AMN Andersen… - European journal of …, 2020 - Springer
Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …

[HTML][HTML] Developmental origins of health and disease theory in cardiology

Y Arima, H Fukuoka - Journal of cardiology, 2020 - Elsevier
Numerous epidemiological and animal studies disclosed that birth weight is inversely
associated with the incidence of the lifestyle-related disorders in adult life, such as …

[HTML][HTML] Parasites and childhood stunting–a mechanistic interplay with nutrition, anaemia, gut health, microbiota, and epigenetics

IL Gabain, AS Ramsteijn, JP Webster - Trends in Parasitology, 2023 - cell.com
Abstract Globally, stunting affects approximately 149.2 million children under 5 years of age.
The underlying aetiology and pathophysiological mechanisms leading to stunting remain …

Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics

J Ding, M Blencowe, T Nghiem, S Ha… - Nucleic Acids …, 2021 - academic.oup.com
The Mergeomics web server is a flexible online tool for multi-omics data integration to derive
biological pathways, networks, and key drivers important to disease pathogenesis and is …

[HTML][HTML] DNA methylation in newborns conceived by assisted reproductive technology

SE Håberg, CM Page, Y Lee, HE Nustad… - Nature …, 2022 - nature.com
Assisted reproductive technology (ART) may affect fetal development through epigenetic
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …

[HTML][HTML] DNA methylation: a potential mediator between air pollution and metabolic syndrome

P Poursafa, Z Kamali, E Fraszczyk, HM Boezen… - Clinical …, 2022 - Springer
Given the global increase in air pollution and its crucial role in human health, as well as the
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …

[HTML][HTML] Genetics, epigenetics and transgenerational transmission of obesity in children

N Panera, C Mandato, A Crudele… - Frontiers in …, 2022 - frontiersin.org
Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …