Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …
disease caused by tobacco smoking in genetically susceptible individuals has been …
[HTML][HTML] Exploring the evidence for epigenetic regulation of environmental influences on child health across generations
CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …
influences that may impact health outcomes directly or via interactions with the genome or …
The social origins of obesity within and across generations
We propose a model for obesity development that traces a considerable part of its origins to
the social domain (mainly different forms of prolonged social adversity), both within and …
the social domain (mainly different forms of prolonged social adversity), both within and …
[HTML][HTML] The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
VWV Jaddoe, JF Felix, AMN Andersen… - European journal of …, 2020 - Springer
Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …
accumulating body of evidence suggests that exposure to adverse stressors during early life …
[HTML][HTML] Developmental origins of health and disease theory in cardiology
Y Arima, H Fukuoka - Journal of cardiology, 2020 - Elsevier
Numerous epidemiological and animal studies disclosed that birth weight is inversely
associated with the incidence of the lifestyle-related disorders in adult life, such as …
associated with the incidence of the lifestyle-related disorders in adult life, such as …
[HTML][HTML] Parasites and childhood stunting–a mechanistic interplay with nutrition, anaemia, gut health, microbiota, and epigenetics
IL Gabain, AS Ramsteijn, JP Webster - Trends in Parasitology, 2023 - cell.com
Abstract Globally, stunting affects approximately 149.2 million children under 5 years of age.
The underlying aetiology and pathophysiological mechanisms leading to stunting remain …
The underlying aetiology and pathophysiological mechanisms leading to stunting remain …
Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics
J Ding, M Blencowe, T Nghiem, S Ha… - Nucleic Acids …, 2021 - academic.oup.com
The Mergeomics web server is a flexible online tool for multi-omics data integration to derive
biological pathways, networks, and key drivers important to disease pathogenesis and is …
biological pathways, networks, and key drivers important to disease pathogenesis and is …
[HTML][HTML] DNA methylation in newborns conceived by assisted reproductive technology
Assisted reproductive technology (ART) may affect fetal development through epigenetic
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …
[HTML][HTML] DNA methylation: a potential mediator between air pollution and metabolic syndrome
Given the global increase in air pollution and its crucial role in human health, as well as the
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …
[HTML][HTML] Genetics, epigenetics and transgenerational transmission of obesity in children
N Panera, C Mandato, A Crudele… - Frontiers in …, 2022 - frontiersin.org
Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …