The physiological control of eating: signals, neurons, and networks

AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding

IC Alcantara, APM Tapia, Y Aponte, MJ Krashes - Nature metabolism, 2022 - nature.com
The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism

D Burstein, TC Griffen, K Therrien, J Bendl… - Nature …, 2023 - nature.com
Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture
remains largely unknown. Studying BED is challenging because it is often comorbid with …

An orexigenic subnetwork within the human hippocampus

DAN Barbosa, S Gattas, JS Salgado, FM Kuijper… - Nature, 2023 - nature.com
Only recently have more specific circuit-probing techniques become available to inform
previous reports implicating the rodent hippocampus in orexigenic appetitive processing …

Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats

KS Subramanian, LT Lauer, AMR Hayes… - Nature …, 2023 - nature.com
The lateral hypothalamic area (LHA) integrates homeostatic processes and reward-
motivated behaviors. Here we show that LHA neurons that produce melanin-concentrating …

Memory and eating: A bidirectional relationship implicated in obesity

MB Parent, S Higgs, LG Cheke, SE Kanoski - … & Biobehavioral Reviews, 2022 - Elsevier
This paper reviews evidence demonstrating a bidirectional relationship between memory
and eating in humans and rodents. In humans, amnesia is associated with impaired …

[HTML][HTML] Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young …

G Li, Y Chen, S Chaudhary, CS Li, D Hao, L Yang… - Neuroimage, 2023 - Elsevier
Background The hypothalamus plays a crucial role in regulating sleep-wake cycle and
motivated behavior. Sleep disturbance is associated with impairment in cognitive and …

Oxytocin and food intake control: Neural, behavioral, and signaling mechanisms

CM Liu, MO Spaulding, JJ Rea, EE Noble… - International Journal of …, 2021 - mdpi.com
The neuropeptide oxytocin is produced in the paraventricular hypothalamic nucleus and the
supraoptic nucleus of the hypothalamus. In addition to its extensively studied influence on …

Ghrelin and glucagon-like peptide-1: a gut-brain axis battle for food reward

L Decarie-Spain, SE Kanoski - Nutrients, 2021 - mdpi.com
Eating behaviors are influenced by the reinforcing properties of foods that can favor
decisions driven by reward incentives over metabolic needs. These food reward-motivated …

Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition

MN Lord, K Subramanian, SE Kanoski, EE Noble - Peptides, 2021 - Elsevier
Given the increased prevalence of obesity and its associated comorbidities, understanding
the mechanisms through which the brain regulates energy balance is of critical importance …