The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

Chemical probes for interrogating biological processes are of considerable current interest.
Cell permeable small molecule tools have a major role in facilitating the functional …

We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence
of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent …

The ERK (extracellular signal-regulated kinase) pathway is an evolutionarily conserved
signal transduction module that controls cellular growth, differentiation and survival …

The BRAFV600E mutation is common in several human cancers, especially melanoma.
RG7204 (PLX4032) is a small-molecule inhibitor of BRAFV600E kinase activity that is in …

The protein kinase BRAF is a key component of the RAS–RAF signaling pathway which
plays an important role in regulating cell proliferation, differentiation, and survival. Mutations …

The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected
signalling pathways involved in diverse cellular processes, such as cell cycle, survival …

Introduction: Because of their important roles in disease and excellent 'druggability', kinases
have become the second largest drug target family. The great success of the BCR-ABL …

Although we have made great progress in understanding the complex genetic alterations
that underlie human cancer, it has proven difficult to identify which molecularly targeted …

Geldanamycin is a benzoquinone ansamycin antibiotic that manifests anti-cancer activity
through the inhibition of HSP90-chaperone function. The HSP90 molecular chaperone is …