Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability
in most patients with estrogen receptor positive breast cancers (ER+ BC). By genomic and …

Background Colon cancer (CC) is a common malignant cancer. Recently, circFNDC3B was
found to exert biological function in multiple cancers. However, it was unclear whether the …

Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …

Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …

Oxidative stress, caused by the imbalance between reactive species generation and the
dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer …

Metabolic reprogramming is a potential hallmark of tumor cells to support continuous
proliferation. Metabolic heterogeneity in breast cancer patients has been highlighted as the …

Background Although produced by several types of tumours, the role of serotonin on cancer
biology is yet to be understood. Methods The effects of serotonin (5-HT) on human breast …