Exploring the enhanced permeability and retention (EPR) effect through therapeutic
nanoparticles has been a subject of considerable interest in tumor biology. This passive …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

Meiosis facilitates diversity across individuals and serves as a major driver of evolution.
However, understanding how meiosis begins is complicated by fundamental differences that …

Background Metabolic stress resulting from nutrient deficiency is one of the hallmarks of a
growing tumour. Here, we tested the hypothesis that metabolic stress induces breast cancer …

CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in
tumor progression, tumor immune escape and resistance to anti-cancer therapeutics …

Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly
dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved …

ABSTRACT SH3PXD2A/TKS5 (SH3 and PX domains 2A) is a scaffold protein that promotes
invadopodia formation and regulates cell migration; therefore, the overexpression of …

Cancer cells are confronted with nutrient deprivation because of high proliferation rate,
especially at the early stage of their development. There is a frequent assumption that …

Background Post-translational modification (PTM) of proteins controls various cellular
functions of transcriptional regulators and participates in diverse signal transduction …

Background: The unique microenvironment in tumors inhibits the normal functioning of
tumor-infiltrating lymphocytes, leading to immune evasion and cancer progression. Over …