Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in
excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first …

Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for
changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the …

Objectives: This randomized controlled multicenter trial evaluated coenzyme Q10 (CoQ10)
as adjunctive treatment in chronic heart failure (HF). Background: CoQ10 is an essential …

There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC)
as a novel and important target for the actions of 17β-estradiol (E2) and estrogen receptors …

Aims Impairment in mitochondrial energetics is a common observation in animal models of
heart failure, the underlying mechanisms of which remain incompletely understood. It was …

Cellular energy homeostasis is a fundamental process that governs the overall health of the
cell and is paramount to cell survival. Central to this is the control of ATP generation and …

People with migraine are prone to a brain energy deficit between attacks, through increased
energy demand (hyperexcitable brain) or decreased supply (mitochondrial impairment) …

Objectives: We investigated the incidence and contribution of the oxidation/nitrosylation of
tropomyosin and actin to the contractile impairment and cardiomyocyte injury occurring in …

The new guidelines classify heart failure (HF) into three subgroups based on the ejection
fraction (EF): HF with reduced EF (HFrEF), HF with mid-range EF (HFmrEF), and HF with …

Mitochondrial function can provide key insights into how fish will respond to climate change,
due to its important role in heart performance, energy metabolism and oxidative stress …